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Postdoctoral position available in the « pathogen/host cell interactions » team
at the Centre of Immunology of Marseille-Luminy (CIML).

Our team is seeking a postdoctoral research associate to investigate the role of
Peyer’s patch phagocytes in mucosal immunity and gut homeostasis

Project: The initiation of the mucosal immune response in Peyer’s patch (PP) relies on the sampling, processing and
efficient presentation of foreign antigens by phagocytes to effector cells. The successful applicant will study the impact
of immunomodulators and bacterial pathogen infection on mouse PP phagocyte stimulation and on the initiation of
the mucosal immune response. He will study the interaction between the gut flora and PP phagocytes and see how it
can modulate this response. Finally, when possible he will translate the results to humans. This work will have
implications for mucosal vaccine targeting approaches and for the development of new strategies to dampen
inflammation in inflammatory bowel diseases.

Candidate qualification: Applicants should have a good track-record with publications in major peer-reviewed
international journals, a strong expertise in mucosal immunology and good skills in microbiology. The project will
require a wide variety of techniques including flow cytometry, microbiology, confocal microscopy and animal
experimentation.

Application: Appointment starts immediately for 2 years. Interested candidates should send a CV with a cover letter
and contact for two referees to Jean-Pierre Gorvel (gorvel@ciml.univ-mrs.fr) and Hugues Lelouard
(lelouard@ciml.univ-mrs.fr).

Selected publications from the host lab:
1-Da Silva, C., Wagner, C.,Bonnardel, J., Gorvel, J. P., and Lelouard, H. (2017) The Peyer's Patch Mononuclear Phagocyte
System at Steady State and during Infection. Front. Immunol. 8, 1254.
2-Bonnardel, J., Da Silva, C., Wagner, C., Bonifay, R., Chasson, L., Masse, M., Pollet, E., Dalod, M., Gorvel, J. P., and
Lelouard, H. (2017) Distribution, location, and transcriptional profile of Peyer's patch conventional DC subsets at steady state
and under TLR7 ligand stimulation. Mucosal. Immunol. 10, 1412-1430.
3-Bonnardel, J., Da Silva, C., Henri, S., Tamoutounour, S., Chasson, L., Montanana-Sanchis, F., Gorvel, J.P., and Lelouard, H.
(2015) Innate and Adaptive Immune Functions of Peyer's Patch Monocyte-Derived Cells. Cell reports 11, 770-784.
4-Lelouard H., Fallet M., de Bovis B., Meresse S., Gorvel J.P. (2012) Peyer's Patch Dendritic Cells Sample Antigens by
Extending Dendrites Through M Cell-Specific Transcellular Pores. Gastroenterology, 142: 592-601.




A Postdoctoral position in Pediatric Cancer research is available in the team "Signaling in
Cancer Progression" (https://science.institut-curie.org/research/biology-chemistry-of-radiationscell-
signaling-and-cancer-axis/umr-3347-normal-and-pathological-signaling/team-eychenepouponnot/
, IC, INSERM U1021, CNRS UMR3347, University Paris Saclay)
under the
supervision of C. Pouponnot at the Curie Institute.


Project:
Rhabdoid tumors (RTs) are deadly aggressive pediatric cancers that arise in the brain, kidney,
liver, and miscellaneous soft-tissues treated by combinations of intensive chemotherapy and
radiotherapy. Our objective is to investigate the modification of the immune landscape in
RTs in response to different modalities of radiotherapy in order to better understand how
radiotherapy could modulate the immune infiltrate and to determine the best combination
between irradiation and immunotherapy by "checkpoint inhibitors" (CPI) in anticipation of a
clinical transfer.

Required profile:
Enthusiastic applicants must have a strong expertise in mouse experimentation including
subcutaneous and orthotopic grafting, molecular biology/biochemistry (FACS, histology, RNA,
proteins…). Since the project is part of a collaborative network, excellent communication skills
are required as well as ability to work with bioinformatician/computational biologist. The
applicant should be able to conduct his/her research independently but also to work as team.
Solid track record is mandatory.

Environment:
This project involves a collaborative network of 4 teams:
- "Signaling in Cancer progression" led by Celio Pouponnot & A. Eychène (IC/UMR3347 CNRS
/ U1021 INSERM/ UPSUD).
- two teams of the U830 INSERM: Josh Waterfall's team (Integrative Functional Genomics of
Cancer, and the "Translational Research in Pediatric Oncology" (Franck Bourdeaut)
- "Translational Research in Immunology" team , directed by Eliane Piaggio (IC/U932 INSERM
directed by Sebastian Amigorena).

Application:
Applications must include a CV with a cover letter and contacts for 2 references
Please apply by email to: celio.pouponnot@curie.fr